New antibody approaches to lymphoma therapy
نویسندگان
چکیده
منابع مشابه
New antibody approaches to lymphoma therapy
The CD20-directed monoclonal antibody rituximab established a new era in lymphoma therapy. Since then other epitopes on the lymphoma surface have been identified as potential targets for monoclonal antibodies (mAb). While most mAbs eliminate lymphoma cells mainly by antibody-dependent cellular cytotoxicity, complement-dependent cytotoxicity or direct cell death, others counter mechanisms utiliz...
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CD19 is expressed on B- lineage cells and follicular dendritic cells and plays a key role in B cell malignancies and autoimmune diseases. Thus, it has been considered as potential target for several monoclonal antibodies (mAbs). For decades, chemotherapy has been known as one of the major antitumor therapies eradicating high proliferative tumor cells. But, anti- CD19 mAbs developed for treating...
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Recent years have brought an explosion of new diagnostic tools to the pathology of lymphomas, which have permitted more precise disease definition and recognition of factors that can predict prognosis and response to treatment. These new methods exploit both the biological features of normal lymphocytes as they progress through differentiation pathways and the genetic abnormalities that charact...
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Köhler and Milstein, their use as a targeted therapy for cancer has been explored widely. Depending on antigen specificity, antibodies have the potential to react preferentially with tumor cells while binding to a lesser degree with normal tissues. This is in great contrast to chemotherapy (and to some degree radiotherapy), where significant toxicity results from drug exposure to various organs...
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ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2014
ISSN: 1756-8722
DOI: 10.1186/s13045-014-0058-4